Thanks uhoh7 and the others.. Yea, you are so right about no such thing as a simple MIDI question. So despite my question, I'm not new to MIDI at all and had similar gear as you do uhoh7. When I was actively gigging my SKB cases were loaded with modules from Korg, Roland, Alesis and others and I drove most of it from an Ensoniq KS-32 and later from a Kurzweil. I even had an Alesis Data Disk in the chain so I could load sound banks on the fly or restore any of my synths should something get corrupted. That never happened. In fact other than the occasional stuck note, everything worked rather well for live performances.
I just hated having to transport it all
So I've been ITB in the studio for many years happily using VSTi but am now looking for ideas to integrate hardware with software, my PC and DAW.
The reason I want to go with DIN is because it's simple and it works. I am OCD with my PC (Intel 9900k, 64g ram, NVME/SSD drives etc) as far as USB ports are concerned and I prefer to keep it as simple as possible since my MOTU AVB interface also runs off USB.
I've been at this for years and many Windows PC systems so I know that for low RTL and little to no DPC spiking (clicks, pops etc), especially with a USB based interface, simple is best. The quality of the driver does have the most effect on RTL, especially under load however, the less USB devices the better. And for the mostly unavoidable like keyboard/mouse, iLok, Steinberg key etc keeping that stuff on a separate system board USB controller chip helps to eliminate problems with the audio interface.
Macs are much better in this regard than Windows systems.
So again, thanks for all the great advice! I'll be testing this out next week and will report back on how well the integration goes.