I have a Marshall AVT275, Fender strat USA series and use the Boss ME-50 fx processor. The other guitarist in our band has exactly the same equipment as me apart from the fx processor. He uses a Boss GT6 and goes through the fx loop whereas I go through the front of my amp. Never been a problem until this week when we needed to turn the volume up a notch to match our new drummer who is a lot louder than the previous one. When I turned my volume up to match the other guitarist I got awful feedback so I tried going through the fx loop. Seemed great until I introduced the tremelo which was so weak it wasn't noticeable and my programmed banks that had distortion/overdrive were all clean?? I have been to 3 music shops and each adviser has given me a different set up, including connecting the send from the rear of the amp to the input on the front of the amp with the fx loop returns connected to the ME-50 outputs. If I didn't have the sense to turn all volumes down beforehand the high pitched sound that came out as I went to turn up might well have deafened me so God knows what it would have done to the amp! Any suggestions? Please bear in mind the following: It is nothing to do with single coil pickups as the other guitarist has the same. I do not have the master volume on ME-50 too high. I have contacted Roland/Boss customer support and finally, I am not technically minded so an idiots guide will be appreciated. Many thanks.