I have an instructional video where Albert Lee is playing lead on a Nashville strung guitar, and it's cool how notes go up when you expect them to go down etc. God help someone trying to figure out those lines on a guitar in regular tuning!

Yeah, Nashville Tuning/Stringing is great! You can look up the gauges of the octave-strings used in a "Medium" 12-string set, to get an idea of what gauges to go with for the 3rd through 6th strings.

You can also go with what's sometimes called "High G" Tuning/Stringing (not to be confused with Dobro High-G!), where you replace only the 3rd/G string with a .010" or .011" and tune it up an octave higher than normal. This gives you the sound of having the highest note in most chords being on the 3rd-string, sort of like a 12 string or "Nashville". I've done all of the above before on acoustic guitars; any and all set your sound apart when playing with several guitarists, particularly with a little attention paid to what register you're playing in and chord voicings.

Note that Wechter makes a couple of specific "Nashville Special Elite" guitar models, made and set-up for "Nashville" tuning from the start. This has some advantages if you don't mind a specialized guitar!

Wechter Nashville Special Elite thread with videos and further links