This can be some what of loaded question, which I am sure will( or maybe not spark alot of debate) Yes there have been major label stuff done on Adat's/Mackies etc.. I.C.P. The Great Milenko and Kings x newest album was done on Adat's, Pantera's latest was done on Da-88's. These are just a few off the top of my head, I have done some major label blues and christian stuff on Adat's and an Amek board, Now alot depends on your skill and ears, and there obviouly is a definite difference in sound between an Adat/Small frame console and a Studer/Otari , Neve/SSL combination, is one better than the other? People will debate that until the cow's come home, Can you do major label stuff on either. Yea, I think it has been proven you can. I would say if you can afford it check out all the options listen to everything (equipment wise,) and buy what is going to work for your situation.