The original sound can be anything. I have fun stuff from Arturia, NI and SampleTank. A search for "best free plugins" will always bring up something fun. Craig A turned me on to Pianoverb, I have dabbled but there is a treasure of coolness just in that one plugin.
Give me a sound and I will make something out of it. I may enhance it or I may create something unrecognizable - I made a cool shaker out of a kick drum from Studio Drummer once but that's simple.
Make a track, copy it, paste in multiple instances in separate tracks. Pitch shift, reverse, modulate, reverb, delay, EQ, distort.
Automate your tracks and create an ever-shifting piece that the supports the build of tension and release.
19 cents flat on one side and 17 cents sharp on the other with thte original in the center will make anything huge and ethereal. Yes, I like prime numbers. No, I don't know why!!! :- D