What's your CPU/RAM and HD or SSD? How low are you able to put the buffer and have it run reliably?
I'm on Win10 on a Dell laptop from 2012 - i7, 32GB RAM, and Intel SSD. I can run in Cantabile at 64 samples on my UR-44 with no issues. In Cubase, I usually bump up to 96 or 128 because I have other tracks running simultaneously.